CK1, GRK2, and another still-unidentified protein kinase phosphorylate the C-tail of mammalian Smo in the presence of Hh proteins (72). signaling pathways. Noncanonical Hh signaling is normally itself subdivided into two distinctive signaling modules: (i) those not really needing Smoothened (Smo) and (ii) those downstream of Smo that usually do not need Gli transcription elements. […]