Here, we examined a series of studies that have begun illuminating the highly diverse tasks of SAMHD1 in virology, immunology, and malignancy biology. promoter methylation directly correlated with low SAMHD1 manifestation in CD4+ cell lines, such as Jurkat and Sup-T, while primary CD4+ lymphocytes harboring unmethylated promoters were characterized by elevated SAMHD1 manifestation [9,58]. (i.e., […]