Alternatively, once the substrate, a counterpart of AICD possibly, is bound to-secretase, it is cleaved at the A40 preferentially, A43, or A46 site, all aligning at one particular -helical surface of CTF, or at the A45 or A42 site, both aligning at the opposite surface (Fig. wtAPP695 and mouse neuroblastoma N2a cells expressing Swedish mtAPP695, […]