This was a little surprising because from the frequently reported anti-apoptotic activity of TRAF2 and a previous report explaining TRAF2-dependent K48 ubiquitination of active caspase-8 by cullin-3 leading to proteasomal degradation of active caspase-8 and an attenuated apoptosis response (9). DRs, but this arrived with a decrease in net caspase-8 activity amazingly. In amount, our […]