That is potentially due to the increased loss of PKA-mediated PDE activation in AKAP-disrupted cells, as PKA may phosphorylate and activate certain PDE isoforms, including PDE4, in other cell types (34, 35). compartmentalized cAMP signaling in ASM cells by regulating multiple components of 2AR-mediated cAMP deposition, thus representing a book focus on for manipulating 2AR […]