It is thus plausible that a vicious cycle of microbial Ro60 ortholog production, UV exposure and anti-Ro60 antibody binding to first microbial, and then hRo60 promotes cutaneous manifestations in lupus patients and Ro60-positive commensals sustain systemic auto-antibodies (fig. (2.8M) GUID:?C55250F1-5C66-4027-800F-493294E78FC2 Abstract The earliest autoantibodies in lupus are directed against the RNA binding autoantigen Ro60, but […]