Indeed, it’s been shownin vitrothat the depolarizing effects of HFS are eliminated by glutamate receptor antagonist drugs,25supporting the hypothesis that glutamate release is crucial to HFS function. with the vesicular H+-ATPase inhibitor, bafilomycin, and the calcium chelator, BAPTA-AM. Furthermore, electrical stimulation of purified primary astrocytic cultures was able to evoke intracellular calcium transients and glutamate […]