All analogues seemed to have increased aqueous solubility in comparison to 1

All analogues seemed to have increased aqueous solubility in comparison to 1. variant to isopropyl in 8 triggered a lack of binding. Six-membered aliphatic bands (10C14) had been better tolerated than analogues including six-membered aromatic part chains (discover Supporting Info), likely because of the greater flexibility. Nevertheless, development to a seven-membered band reduced activity. Desk […]

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