(a) RT112 cells were treated with the indicated inhibitors at 1?m for 5 days and assayed for cell death

(a) RT112 cells were treated with the indicated inhibitors at 1?m for 5 days and assayed for cell death. and cholesterol biosynthesis in sensitive cell lines. Remarkably, loss of viability can be rescued by saturating cellular membranes with cholesterol or recapitulated by statin-mediated inhibition, or small interfering RNA knockdown, of enzymes regulating cholesterol metabolism. Modulation […]

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